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HFEPX · Eval paper review

Perturbation-based Regional Interpretability through Subtraction Mapping (PRISM): naming-error dissociations in language models and post-stroke aphasia

Xiang Guan, Roger D. Newman-Norlund, Yong Yang, Saeed Ahmadi +7 more

Published

Aug 13, 2026

Citations

0

Trust level

Low

Usefulness score

40/100 (Low)

Extraction confidence

45% (Low)

Derived from extracted protocol signals and abstract evidence.

Rater population

Not reported

Signals refreshed

Aug 13, 2026

Should you rely on this paper?

This paper is adjacent to HFEPX scope and is best used for background context, not as a primary protocol reference.

Use this as background context only. Do not make protocol decisions from this page alone.

Best use

Background context only

Use if you need

Background context only.

What to verify

Read the full paper before copying any benchmark, metric, or protocol choices.

Main weakness

The available metadata is too thin to trust this as a primary source.

Human feedback signal
Detected
From extracted signals
Evaluation signal
Weak or implicit
Validate from full paper
Usefulness for eval research
40/100
Adjacent candidate

Treat as adjacent context, not a core eval-method reference.

Abstract

Mechanistic interpretability of large language models lacks spatially resolved, falsifiable tools for testing whether internal components are specialized for distinct cognitive operations. We adapt subtraction analysis, the standard framework of human neuroimaging, from biological brains to perturbed transformers, and apply the same logic to both substrates in parallel. Building on the Brain-LLM Unified Model (BLUM), which showed that layer-perturbed LLaVA-1.6-Vicuna-13B error profiles match the lesion patterns of aphasic patients, we develop PRISM (Perturbation-based Regional Interpretability through Subtraction Mapping). PRISM maps the seven clinical Philadelphia Naming Test categories, subtracts error classes pairwise, and treats each perturbation seed as a subject in a group analysis with threshold-free cluster enhancement along the layer axis. We run a structurally matched analysis on 213 chronic post-stroke aphasia patients using correlation-difference lesion-symptom mapping, and replicate both sides on held-out splits. The designs match in subject dimension (seeds, patients), spatial dimension (layers, atlas-parcellated cortex) and thresholding, but the contrast operator differs: a within-subject error-proportion difference for the LLM, a between-subject correlation difference for the cortex. Both substrates recover a robust phonemic-favoring dissociation, a deep layer cluster and a frontal-perisylvian cortical cluster, both replicating; the semantic-favoring direction is a consistently signed but non-significant trend on both. PRISM thus gives a falsifiable, spatially resolved test of functional-specialization claims in transformer language models. A confirmatory ROI-level intervention (PRISM Stage 3) licensing the strongest causal-mechanism claim is left to subsequent work.

What we could verify

These are the protocol signals we could actually recover from the available paper metadata. Use them to decide whether this paper is worth deeper reading.

Human Feedback Types

partial

Pairwise Preference

Directly usable for protocol triage.

"Mechanistic interpretability of large language models lacks spatially resolved, falsifiable tools for testing whether internal components are specialized for distinct cognitive operations."

Evaluation Modes

missing

None explicit

Validate eval design from full paper text.

"Mechanistic interpretability of large language models lacks spatially resolved, falsifiable tools for testing whether internal components are specialized for distinct cognitive operations."

Quality Controls

missing

Not reported

No explicit QC controls found.

"Mechanistic interpretability of large language models lacks spatially resolved, falsifiable tools for testing whether internal components are specialized for distinct cognitive operations."

Benchmarks / Datasets

missing

Not extracted

No benchmark anchors detected.

"Mechanistic interpretability of large language models lacks spatially resolved, falsifiable tools for testing whether internal components are specialized for distinct cognitive operations."

Reported Metrics

missing

Not extracted

No metric anchors detected.

"Mechanistic interpretability of large language models lacks spatially resolved, falsifiable tools for testing whether internal components are specialized for distinct cognitive operations."

Benchmarks and datasets

No benchmark or dataset names were extracted from the available abstract.

Reported metrics

No metric terms were extracted from the available abstract.

Human feedback details
Uses human feedback
Yes
Feedback types
Pairwise Preference
Rater population
Not reported
Unit of annotation
Pairwise (inferred)
Expertise required
Medicine
Evaluation details
Evaluation modes
None
Agentic eval
None
Quality controls
Not reported
Evidence quality
Low
Use this page as
Background context only

Research brief

Metadata summary

Mechanistic interpretability of large language models lacks spatially resolved, falsifiable tools for testing whether internal components are specialized for distinct cognitive operations.

Based on abstract + metadata only. Check the source paper before making high-confidence protocol decisions.

Key takeaways

  • Mechanistic interpretability of large language models lacks spatially resolved, falsifiable tools for testing whether internal components are specialized for distinct cognitive operations.
  • We adapt subtraction analysis, the standard framework of human neuroimaging, from biological brains to perturbed transformers, and apply the same logic to both substrates in parallel.
  • Building on the Brain-LLM Unified Model (BLUM), which showed that layer-perturbed LLaVA-1.6-Vicuna-13B error profiles match the lesion patterns of aphasic patients, we develop PRISM (Perturbation-based Regional Interpretability through Subtraction Mapping).

Researcher actions

  • Compare this paper against nearby papers in the same arXiv category before using it for protocol decisions.
  • Check the full text for explicit evaluation design choices (raters, protocol, and metrics).
  • Use related-paper links to find stronger protocol-specific references.

Caveats

  • Generated from abstract + metadata only; no PDF parsing.
  • Signals below are heuristic and may miss details reported outside the abstract.

Contribution summary

  • We adapt subtraction analysis, the standard framework of human neuroimaging, from biological brains to perturbed transformers, and apply the same logic to both substrates in parallel.
  • Building on the Brain-LLM Unified Model (BLUM), which showed that layer-perturbed LLaVA-1.6-Vicuna-13B error profiles match the lesion patterns of aphasic patients, we develop PRISM (Perturbation-based Regional Interpretability through…

Why it matters for eval

  • We adapt subtraction analysis, the standard framework of human neuroimaging, from biological brains to perturbed transformers, and apply the same logic to both substrates in parallel.

Researcher checklist

  • Human feedback protocol is explicit

    Detected: Pairwise Preference

  • Evaluation mode is explicit

    No clear evaluation mode extracted.

  • Quality control reporting appears

    No calibration/adjudication/IAA control explicitly detected.

  • Benchmark or dataset anchors are present

    No benchmark/dataset anchor extracted from abstract.

  • Metric reporting is present

    No metric terms extracted.