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HFEPX · Eval paper review

ClinicalAgents: Multi-Agent Orchestration for Clinical Decision Making with Dual-Memory

Zhuohan Ge, Haoyang Li, Yubo Wang, Nicole Hu +2 more

Published

Mar 27, 2026

Citations

0

Trust level

Moderate

Usefulness score

65/100 (Medium)

Extraction confidence

70% (Moderate)

Derived from extracted protocol signals and abstract evidence.

Rater population

Domain Experts

Signals refreshed

Mar 27, 2026

Should you rely on this paper?

This paper has useful evaluation signal, but protocol completeness is partial; pair it with related papers before deciding implementation strategy.

Use this for comparison and orientation, not as your only source.

Best use

Secondary protocol comparison source

Use if you need

A secondary eval reference to pair with stronger protocol papers.

What to verify

Validate the evaluation procedure and quality controls in the full paper before operational use.

Main weakness

No major weakness surfaced.

Human feedback signal
Detected
From extracted signals
Evaluation signal
Detected
Eval setup described
Usefulness for eval research
65/100
Moderate-confidence candidate

Useful as a secondary reference; validate protocol details against neighboring papers.

Abstract

While Large Language Models (LLMs) have demonstrated potential in healthcare, they often struggle with the complex, non-linear reasoning required for accurate clinical diagnosis. Existing methods typically rely on static, linear mappings from symptoms to diagnoses, failing to capture the iterative, hypothesis-driven reasoning inherent to human clinicians. To bridge this gap, we introduce ClinicalAgents, a novel multi-agent framework designed to simulate the cognitive workflow of expert clinicians. Unlike rigid sequential chains, ClinicalAgents employs a dynamic orchestration mechanism modeled as a Monte Carlo Tree Search (MCTS) process. This allows an Orchestrator to iteratively generate hypotheses, actively verify evidence, and trigger backtracking when critical information is missing. Central to this framework is a Dual-Memory architecture: a mutable Working Memory that maintains the evolving patient state for context-aware reasoning, and a static Experience Memory that retrieves clinical guidelines and historical cases via an active feedback loop. Extensive experiments demonstrate that ClinicalAgents achieves state-of-the-art performance, significantly enhancing both diagnostic accuracy and explainability compared to strong single-agent and multi-agent baselines.

What we could verify

These are the protocol signals we could actually recover from the available paper metadata. Use them to decide whether this paper is worth deeper reading.

Human Feedback Types

strong

Expert Verification

Directly usable for protocol triage.

"While Large Language Models (LLMs) have demonstrated potential in healthcare, they often struggle with the complex, non-linear reasoning required for accurate clinical diagnosis."

Evaluation Modes

strong

Automatic Metrics

Includes extracted eval setup.

"While Large Language Models (LLMs) have demonstrated potential in healthcare, they often struggle with the complex, non-linear reasoning required for accurate clinical diagnosis."

Quality Controls

missing

Not reported

No explicit QC controls found.

"While Large Language Models (LLMs) have demonstrated potential in healthcare, they often struggle with the complex, non-linear reasoning required for accurate clinical diagnosis."

Benchmarks / Datasets

missing

Not extracted

No benchmark anchors detected.

"While Large Language Models (LLMs) have demonstrated potential in healthcare, they often struggle with the complex, non-linear reasoning required for accurate clinical diagnosis."

Reported Metrics

strong

Accuracy

Useful for evaluation criteria comparison.

"Extensive experiments demonstrate that ClinicalAgents achieves state-of-the-art performance, significantly enhancing both diagnostic accuracy and explainability compared to strong single-agent and multi-agent baselines."

Rater Population

strong

Domain Experts

Helpful for staffing comparability.

"To bridge this gap, we introduce ClinicalAgents, a novel multi-agent framework designed to simulate the cognitive workflow of expert clinicians."

Benchmarks and datasets

No benchmark or dataset names were extracted from the available abstract.

Reported metrics

accuracy
Human feedback details
Uses human feedback
Yes
Feedback types
Expert Verification
Rater population
Domain Experts
Expertise required
Medicine
Evaluation details
Evaluation modes
Automatic Metrics
Agentic eval
Multi Agent
Quality controls
Not reported
Evidence quality
Moderate
Use this page as
Secondary protocol comparison source

Research brief

Metadata summary

While Large Language Models (LLMs) have demonstrated potential in healthcare, they often struggle with the complex, non-linear reasoning required for accurate clinical diagnosis.

Based on abstract + metadata only. Check the source paper before making high-confidence protocol decisions.

Key takeaways

  • While Large Language Models (LLMs) have demonstrated potential in healthcare, they often struggle with the complex, non-linear reasoning required for accurate clinical diagnosis.
  • Existing methods typically rely on static, linear mappings from symptoms to diagnoses, failing to capture the iterative, hypothesis-driven reasoning inherent to human clinicians.
  • To bridge this gap, we introduce ClinicalAgents, a novel multi-agent framework designed to simulate the cognitive workflow of expert clinicians.

Researcher actions

  • Compare this paper against nearby papers in the same arXiv category before using it for protocol decisions.
  • Validate inferred eval signals (Automatic metrics) against the full paper.
  • Use related-paper links to find stronger protocol-specific references.

Caveats

  • Generated from abstract + metadata only; no PDF parsing.
  • Signals below are heuristic and may miss details reported outside the abstract.

Contribution summary

  • Existing methods typically rely on static, linear mappings from symptoms to diagnoses, failing to capture the iterative, hypothesis-driven reasoning inherent to human clinicians.
  • To bridge this gap, we introduce ClinicalAgents, a novel multi-agent framework designed to simulate the cognitive workflow of expert clinicians.
  • Extensive experiments demonstrate that ClinicalAgents achieves state-of-the-art performance, significantly enhancing both diagnostic accuracy and explainability compared to strong single-agent and multi-agent baselines.

Why it matters for eval

  • To bridge this gap, we introduce ClinicalAgents, a novel multi-agent framework designed to simulate the cognitive workflow of expert clinicians.
  • Extensive experiments demonstrate that ClinicalAgents achieves state-of-the-art performance, significantly enhancing both diagnostic accuracy and explainability compared to strong single-agent and multi-agent baselines.

Researcher checklist

  • Human feedback protocol is explicit

    Detected: Expert Verification

  • Evaluation mode is explicit

    Detected: Automatic Metrics

  • Quality control reporting appears

    No calibration/adjudication/IAA control explicitly detected.

  • Benchmark or dataset anchors are present

    No benchmark/dataset anchor extracted from abstract.

  • Metric reporting is present

    Detected: accuracy