HFEPX · Eval paper review

FEAST: Fully Connected Expressive Attention for Spatial Transcriptomics

Taejin Jeong, Joohyeok Kim, Jinyeong Kim, Chanyoung Kim +1 more

Published

Mar 26, 2026

Citations

Trust level

Moderate

Usefulness score

40/100 (Low)

Extraction confidence

50% (Moderate)

Derived from extracted protocol signals and abstract evidence.

Rater population

Not reported

Signals refreshed

Mar 26, 2026

Open arXiv Find implementation Shortlist (0) RSS feed

Should you rely on this paper?

This paper is adjacent to HFEPX scope and is best used for background context, not as a primary protocol reference.

Use this for comparison and orientation, not as your only source.

Low-signal caution for protocol decisions

Use this page for context, then validate protocol choices against stronger HFEPX references before implementation decisions.

The abstract does not clearly describe the evaluation setup.
The abstract does not clearly name benchmarks or metrics.

Best use

Background context only

Use if you need

Background context only.

What to verify

Read the full paper before copying any benchmark, metric, or protocol choices.

Main weakness

The abstract does not clearly describe the evaluation setup.

Human feedback signal

Detected

From extracted signals

Evaluation signal

Weak or implicit

Validate from full paper

Usefulness for eval research

40/100

Adjacent candidate

Treat as adjacent context, not a core eval-method reference.

If you are doing eval pipeline work, start here

Human Eval Papers LLM-as-Judge Papers Pairwise Preference Papers Tool-Use Evaluation Search

Abstract

Spatial Transcriptomics (ST) provides spatially-resolved gene expression, offering crucial insights into tissue architecture and complex diseases. However, its prohibitive cost limits widespread adoption, leading to significant attention on inferring spatial gene expression from readily available whole slide images. While graph neural networks have been proposed to model interactions between tissue regions, their reliance on pre-defined sparse graphs prevents them from considering potentially interacting spot pairs, resulting in a structural limitation in capturing complex biological relationships. To address this, we propose FEAST (Fully connected Expressive Attention for Spatial Transcriptomics), an attention-based framework that models the tissue as a fully connected graph, enabling the consideration of all pairwise interactions. To better reflect biological interactions, we introduce negative-aware attention, which models both excitatory and inhibitory interactions, capturing essential negative relationships that standard attention often overlooks. Furthermore, to mitigate the information loss from truncated or ignored context in standard spot image extraction, we introduce an off-grid sampling strategy that gathers additional images from intermediate regions, allowing the model to capture a richer morphological context. Experiments on public ST datasets show that FEAST surpasses state-of-the-art methods in gene expression prediction while providing biologically plausible attention maps that clarify positive and negative interactions. Our code is available at https://github.com/starforTJ/ FEAST.

What we could verify

These are the protocol signals we could actually recover from the available paper metadata. Use them to decide whether this paper is worth deeper reading.