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Contradictions in Context: Challenges for Retrieval-Augmented Generation in Healthcare

Saeedeh Javadi, Sara Mirabi, Manan Gangar, Bahadorreza Ofoghi · Nov 10, 2025 · Citations: 0

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How to use this paper page

Coverage: Recent

Use this page to decide whether the paper is strong enough to influence an eval design. It summarizes the abstract plus available structured metadata. If the signal is thin, use it as background context and compare it against stronger hub pages before making protocol choices.

Best use

Background context only

Metadata: Recent

Trust level

Provisional

Signals: Recent

What still needs checking

Structured extraction is still processing; current fields are metadata-first.

Signal confidence unavailable

Abstract

In high-stakes information domains such as healthcare, where large language models (LLMs) can produce hallucinations or misinformation, retrieval-augmented generation (RAG) has been proposed as a mitigation strategy, grounding model outputs in external, domain-specific documents. Yet, this approach can introduce errors when source documents contain outdated or contradictory information. This work investigates the performance of five LLMs in generating RAG-based responses to medicine-related queries. Our contributions are three-fold: i) the creation of a benchmark dataset using consumer medicine information documents from the Australian Therapeutic Goods Administration (TGA), where headings are repurposed as natural language questions, ii) the retrieval of PubMed abstracts using TGA headings, stratified across multiple publication years, to enable controlled temporal evaluation of outdated evidence, and iii) a comparative analysis of the frequency and impact of outdated or contradictory content on model-generated responses, assessing how LLMs integrate and reconcile temporally inconsistent information. Our findings show that contradictions between highly similar abstracts do, in fact, degrade performance, leading to inconsistencies and reduced factual accuracy in model answers. These results highlight that retrieval similarity alone is insufficient for reliable medical RAG and underscore the need for contradiction-aware filtering strategies to ensure trustworthy responses in high-stakes domains.

Use caution before copying this protocol

Use this page for context, then validate protocol choices against stronger HFEPX references before implementation decisions.

  • Structured extraction is still processing; current fields are metadata-first.
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HFEPX Relevance Assessment

Signal extraction is still processing. This page currently shows metadata-first guidance until structured protocol fields are ready.

Best use

Background context only

Use if you need

A provisional background reference while structured extraction finishes.

Main weakness

Structured extraction is still processing; current fields are metadata-first.

Trust level

Provisional

Eval-Fit Score

Unavailable

Eval-fit score is unavailable until extraction completes.

Human Feedback Signal

Not explicit in abstract metadata

Evaluation Signal

Weak / implicit signal

HFEPX Fit

Provisional (processing)

Extraction confidence: Provisional

If you are doing eval pipeline work, start here:

Human Eval Hub LLM-as-Judge Hub Pairwise Preference Hub Tool-Use Eval Hub

What This Page Found In The Paper

Each field below shows whether the signal looked explicit, partial, or missing in the available metadata. Use this to judge what is safe to trust directly and what still needs full-paper validation.

Human Feedback Types

provisional

None explicit

Confidence: Provisional Best-effort inference

No explicit feedback protocol extracted.

Evidence snippet: In high-stakes information domains such as healthcare, where large language models (LLMs) can produce hallucinations or misinformation, retrieval-augmented generation (RAG) has been proposed as a mitigation strategy, grounding model outputs in external, domain-specific documents.

Evaluation Modes

provisional

Automatic metrics

Confidence: Provisional Best-effort inference

Includes extracted eval setup.

Evidence snippet: In high-stakes information domains such as healthcare, where large language models (LLMs) can produce hallucinations or misinformation, retrieval-augmented generation (RAG) has been proposed as a mitigation strategy, grounding model outputs in external, domain-specific documents.

Quality Controls

provisional

Not reported

Confidence: Provisional Best-effort inference

No explicit QC controls found.

Evidence snippet: In high-stakes information domains such as healthcare, where large language models (LLMs) can produce hallucinations or misinformation, retrieval-augmented generation (RAG) has been proposed as a mitigation strategy, grounding model outputs in external, domain-specific documents.

Benchmarks / Datasets

provisional

Not extracted

Confidence: Provisional Best-effort inference

No benchmark anchors detected.

Evidence snippet: In high-stakes information domains such as healthcare, where large language models (LLMs) can produce hallucinations or misinformation, retrieval-augmented generation (RAG) has been proposed as a mitigation strategy, grounding model outputs in external, domain-specific documents.

Reported Metrics

provisional

Accuracy

Confidence: Provisional Best-effort inference

Useful for evaluation criteria comparison.

Evidence snippet: Our findings show that contradictions between highly similar abstracts do, in fact, degrade performance, leading to inconsistencies and reduced factual accuracy in model answers.

Rater Population

provisional

Unknown

Confidence: Provisional Best-effort inference

Rater source not explicitly reported.

Evidence snippet: In high-stakes information domains such as healthcare, where large language models (LLMs) can produce hallucinations or misinformation, retrieval-augmented generation (RAG) has been proposed as a mitigation strategy, grounding model outputs in external, domain-specific documents.

Human Data Lens

This page is using abstract-level cues only right now. Treat the signals below as provisional.

  • Potential human-data signal: No explicit human-data keywords detected.
  • Potential benchmark anchors: No benchmark names detected in abstract.
  • Abstract highlights: 3 key sentence(s) extracted below.

Evaluation Lens

Evaluation fields are inferred from the abstract only.

  • Potential evaluation modes: Automatic metrics
  • Potential metric signals: Accuracy
  • Confidence: Provisional (metadata-only fallback).

Research Brief

Metadata summary

In high-stakes information domains such as healthcare, where large language models (LLMs) can produce hallucinations or misinformation, retrieval-augmented generation (RAG) has been proposed as a mitigation strategy, grounding model outputs in external, domain-specific documents.

Based on abstract + metadata only. Check the source paper before making high-confidence protocol decisions.

Key Takeaways

  • In high-stakes information domains such as healthcare, where large language models (LLMs) can produce hallucinations or misinformation, retrieval-augmented generation (RAG) has been proposed as a mitigation strategy, grounding model outputs in external, domain-specific documents.
  • Yet, this approach can introduce errors when source documents contain outdated or contradictory information.
  • This work investigates the performance of five LLMs in generating RAG-based responses to medicine-related queries.

Researcher Actions

  • Compare this paper against nearby papers in the same arXiv category before using it for protocol decisions.
  • Validate inferred eval signals (Automatic metrics) against the full paper.
  • Use related-paper links to find stronger protocol-specific references.

Caveats

  • Generated from abstract + metadata only; no PDF parsing.
  • Signals below are heuristic and may miss details reported outside the abstract.

Recommended Queries

Accuracy

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