Guideline-Grounded Evidence Accumulation for High-Stakes Agent Verification
Yichi Zhang, Nabeel Seedat, Yinpeng Dong, Peng Cui, Jun Zhu, Mihaela van de Schaar · Mar 3, 2026 · Citations: 0
How to use this page
High trustUse this as a practical starting point for protocol research, then validate against the original paper.
Best use
Primary protocol reference for eval design
What to verify
Validate the exact study setup in the full paper before operational use.
Evidence quality
High
Derived from extracted protocol signals and abstract evidence.
Abstract
As LLM-powered agents have been used for high-stakes decision-making, such as clinical diagnosis, it becomes critical to develop reliable verification of their decisions to facilitate trustworthy deployment. Yet, existing verifiers usually underperform owing to a lack of domain knowledge and limited calibration. To address this, we establish GLEAN, an agent verification framework with Guideline-grounded Evidence Accumulation that compiles expert-curated protocols into trajectory-informed, well-calibrated correctness signals. GLEAN evaluates the step-wise alignment with domain guidelines and aggregates multi-guideline ratings into surrogate features, which are accumulated along the trajectory and calibrated into correctness probabilities using Bayesian logistic regression. Moreover, the estimated uncertainty triggers active verification, which selectively collects additional evidence for uncertain cases via expanding guideline coverage and performing differential checks. We empirically validate GLEAN with agentic clinical diagnosis across three diseases from the MIMIC-IV dataset, surpassing the best baseline by 12% in AUROC and 50% in Brier score reduction, which confirms the effectiveness in both discrimination and calibration. In addition, the expert study with clinicians recognizes GLEAN's utility in practice.