Assessing Large Language Models for Medical QA: Zero-Shot and LLM-as-a-Judge Evaluation
Shefayat E Shams Adib, Ahmed Alfey Sani, Ekramul Alam Esham, Ajwad Abrar, Tareque Mohmud Chowdhury · Feb 16, 2026 · Citations: 0
How to use this page
Low trustUse this as background context only. Do not make protocol decisions from this page alone.
Best use
Background context only
What to verify
Validate the evaluation procedure and quality controls in the full paper before operational use.
Evidence quality
Low
Derived from extracted protocol signals and abstract evidence.
Abstract
Recently, Large Language Models (LLMs) have gained significant traction in medical domain, especially in developing a QA systems to Medical QA systems for enhancing access to healthcare in low-resourced settings. This paper compares five LLMs deployed between April 2024 and August 2025 for medical QA, using the iCliniq dataset, containing 38,000 medical questions and answers of diverse specialties. Our models include Llama-3-8B-Instruct, Llama 3.2 3B, Llama 3.3 70B Instruct, Llama-4-Maverick-17B-128E-Instruct, and GPT-5-mini. We are using a zero-shot evaluation methodology and using BLEU and ROUGE metrics to evaluate performance without specialized fine-tuning. Our results show that larger models like Llama 3.3 70B Instruct outperform smaller models, consistent with observed scaling benefits in clinical tasks. It is notable that, Llama-4-Maverick-17B exhibited more competitive results, thus highlighting evasion efficiency trade-offs relevant for practical deployment. These findings align with advancements in LLM capabilities toward professional-level medical reasoning and reflect the increasing feasibility of LLM-supported QA systems in the real clinical environments. This benchmark aims to serve as a standardized setting for future study to minimize model size, computational resources and to maximize clinical utility in medical NLP applications.