Fine-Tuning A Large Language Model for Systematic Review Screening
Kweku Yamoah, Noah Schroeder, Emmanuel Dorley, Neha Rani, Caleb Schutz · Mar 25, 2026 · Citations: 0
How to use this page
Low trustUse this as background context only. Do not make protocol decisions from this page alone.
Best use
Background context only
What to verify
Validate the evaluation procedure and quality controls in the full paper before operational use.
Evidence quality
Low
Derived from extracted protocol signals and abstract evidence.
Abstract
Systematic reviews traditionally have taken considerable amounts of human time and energy to complete, in part due to the extensive number of titles and abstracts that must be reviewed for potential inclusion. Recently, researchers have begun to explore how to use large language models (LLMs) to make this process more efficient. However, research to date has shown inconsistent results. We posit this is because prompting alone may not provide sufficient context for the model(s) to perform well. In this study, we fine-tune a small 1.2 billion parameter open-weight LLM specifically for study screening in the context of a systematic review in which humans rated more than 8500 titles and abstracts for potential inclusion. Our results showed strong performance improvements from the fine-tuned model, with the weighted F1 score improving 80.79% compared to the base model. When run on the full dataset of 8,277 studies, the fine-tuned model had 86.40% agreement with the human coder, a 91.18% true positive rate, a 86.38% true negative rate, and perfect agreement across multiple inference runs. Taken together, our results show that there is promise for fine-tuning LLMs for title and abstract screening in large-scale systematic reviews.